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I've had multiple patients on compounded tirzepatide with niacinamide tell me their skin looks and feels better. And I'm intrigued. We know topical niacinamide supports the skin barrier, reduces redness, and 8 months and 86 lbs later : r Zepbound Tirzepatide Cost: Pricing Breakdown for Weight Loss Patients Dr. Brandon Richland, MD are side effects worse on semaglutide or tirzepatide Not all GLP 1s are the same! Semaglutide Tirzepatide Compounded dual GIP GLP 1 medication Ozari Health Weaning off a GLP 1? Tips for the transition Harvard Health
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.6 ★★★★★
Based on 1058 reviews
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Product Reviews
★★★★★ 4
Helped calm my damaged skin barrier, but expect stinging on very raw skin
Style: Restorative Protective Cream-1.3 Fl Oz
I bought this because I severely damaged my skin barrier and needed something gentle that would help my skin calm down and heal. My skin was extremely sensitive, raw, irritated, tight, and honestly uncomfortable even with water touching it.
This did help, but I do want to mention that if your skin is VERY damaged or raw, there can be some stinging at first. I experienced that myself during the first few applications. The stinging didn’t last long for me, but I think it’s important to mention because people with damaged barriers are usually desperate for relief and can panic when products sting.
What ended up helping me most was using this as part of a simple barrier repair routine instead of using it alone.
What I personally did:
* Wet my face first with either water or Avène Thermal Spring Water so my skin was damp but not soaking wet
* Applied the Avène Cicalfate onto the damp skin
* At night, I sealed everything in with CeraVe Healing Ointment (Aquaphor would probably work too)
I repeated this every night before bed and sometimes during the day if I was staying home.
If I was leaving the house during the day, I would do the same steps but use sunscreen instead of sealing with ointment. I honestly think sunscreen is extremely important when your skin barrier is damaged and trying to heal because irritated skin feels even more sensitive when exposed to sunlight.
I used this day and night, very easy to use, and didn’t experience breakouts from it. The texture is thick but comforting once applied, especially when your skin feels dry and stripped.
Overall, I would buy this again. I don’t think it’s some overnight miracle product, but it genuinely helped my skin calm down and recover when my barrier was damaged. I personally didn’t notice any strong fragrance, which I appreciated since my skin was already extremely irritated. I also like how versatile this product is. Even though I originally bought it for barrier damage, I can see why people use it for irritation from retinol, over-exfoliating, dry patches, or skin that just feels compromised in general.
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Reviewed in the United States on May 14, 2026
★★★★★ 5
Holy Grail of Moisturizers
Style: Restorative Protective Cream-3.3 Fl Oz
I bought this after hearing a dermatologist on Instagram rave about this cream and now I see why. As someone who suffers from pretty severe eczema this is my go to holy grail for flair ups. Perfect for sensitive skin and can be used daily. It is very thick so provides a thick layer of moisture on your skin. I will say I have bought 2 sizes in this and the smaller size (1.3fl oz) did separate and had a liquid part that would come out. I have bought numerous tubes of the larger size (3.3fl oz) and never had an issue with separation with the larger size. I’m learning as I get older that more expensive does not mean better quality skincare. This is one that is not only affordable, but will also give you noticeable results. I have everyone in my whole family using this product!
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Reviewed in the United States on May 17, 2026
★★★★★ 5
Saved my skin barrier!!
I rarely write reviews, but this product truly deserves it. I have sensitive, dry skin with mild to moderate rosacea that became even more fragile after chemotherapy. While trying to repair my skin barrier, I overdid it with actives and completely wrecked my skin — it was red, raw, burning, and peeling.
I turned to ChatGPT for help, and this Avene Cicalfate+ was one of the top recommendations. I started using it about three weeks ago, and wow — the difference is incredible! My skin has healed beautifully. The redness is dramatically reduced, the irritation is gone, and my skin feels soft, smooth, and calm again.
The texture is soft and luxurious without being sticky. I love that there’s no noticeable scent, which is perfect for sensitive skin. It arrived well packaged and intact. For the results it delivers, I consider it an amazing value and will absolutely repurchase again and again.
If you’re on the fence about trying this, go for it — it truly rescued and revived my skin barrier. This is now a permanent part of my routine and 100% a holy grail product for me!
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Reviewed in the United States on October 23, 2025
★★★★★ 5
Hydrating and Powerful Barrier Repair Serum!💧
This serum has been life-changing in calming and restoring my skin barrier. It absorbs quickly, feels lightweight, and instantly soothes irritation without feeling greasy. I’ve noticed my skin looks healthier and more balanced after just a few uses. It’s gentle enough for sensitive skin and works especially well when my skin barrier feels compromised. It is also fragrance-free, which I always appreciate! Trust me, it’s well worth the money!
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Reviewed in the United States on December 28, 2025
★★★★★ 5
Works as created.
Have been using for a few weeks and have noticed 15% improvement in skin and issues. I did notice a difference in the first 24 hours as advertised. It is suggested need a full month I think to see the true results.
At 50 I have pre menopausal skin issues- the redness & inflammation, acne, tightness and sensitivity. It is helping in addition to the other Avene skin products that come in the trial box for sensitive or SOS skin box trial size I think ot is called.
This has made a difference. It is easy to apply. I use morning and night. It is different from the Cicalfate + Cream. I use that also as needed. I am happy and recommend it. The price is higher than what I spend. But I wanted to try it to see of i need more than just what was in the Avene sensitive skin trial size box they have. My skin is really red and irritated so the $40 for the bottle is was willing to try because it's painful on my face.
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Reviewed in the United States on April 23, 2026
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